SIRT3 and metabolic dysfunction-associated steatotic liver disease: Overexpression of SIRT3 protected hepatocytes from lipotoxicity-induced cell death and was found to be protective against nonalcoholic fatty liver disease (NAFLD) [34], whereas suppression of SIRT3 led to the increase in mitochondrial protein acetylation and further increased hepatocyte susceptibility to lipotoxicity-induced cell death [34, 35].