NFE2L2 and neuroblastoma: By analogy, pretreatment with C60(OH)24 showed significant protective effects in the 1-methyl-4-phenylpyridinium- (MPP+-) induced acute cellular Parkinson disease model in human neuroblastoma cells through increase in expression of Nrf2 and expression and activity of γ-glutamyl cysteine ligase and the level of glutathione [28].