Whereas Sema4D levels were not different between RA patients and controls (88.3 [57.5–164.5] versus 91.1 [54.5–147.1] ng/mL, p = 0.617), Sema3A levels in RA patients were significantly higher than those in controls (0.44 [0–1.84] versus 0 [0–0.14], p < 0.001). This evidence concerns the gene SEMA4D and rheumatoid arthritis.