In 2013 it was discovered that ASE, at the death-associated protein kinase 1 (DAPK1) gene locus, was potentially predisposed to chronic lymphocytic leukemia (CLL) using a single-nucleotide primer extension (SNuPE) and MALDI-TOF mass spectrometry (Wei et al., 2013). This evidence concerns the gene DAPK1 and B-cell chronic lymphocytic leukemia.