In terms of diseases, many different ANG gene mutations have been identified in patients with amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (Tello-Montoliu et al., 2006; Gao and Xu, 2008), implying that ANG-catalyzed production of tRNA halves could be involved in the pathogenesis of these neurodegenerative disorders (Thiyagarajan et al., 2012). This evidence concerns the gene ANG and amyotrophic lateral sclerosis.