Furthermore the deficiency of the Mgat5 gene, that encodes for a Golgi branching enzyme N-acetylglucosaminyltransferase V (GnT-V) was shown to markedly increases TCR clustering and signaling at the immune synapse, resulting in a lower T cell activation threshold and increased incidence of autoimmune disease in vivo and in human (30). The gene discussed is MGAT5; the disease is autoimmune disease.