TNFSF14 and Miyoshi myopathy: In the pathogenesis of multiple myeloma (MM), the immortalization of a MM propagating cell is induced by an initiating “hit.” The subsequent accumulation of genetic “hits” in a multistep process leads to the typical MM characteristics: the proliferation of monoclonal plasma cells and the consequent overproduction of immunoglobulin or light chains that can cause end-organ damage and specific symptoms (i.e., bone disease, anemia, renal failure, and hypercalcemia) (1, 2).