These cells respond in a highly pro-inflammatory manner to TLR stimulation, express reactive oxygen intermediates, produce high levels of IL1β, IL6, IL12, IL23, and TNFα and express high levels of TREM1 (5, 9, 17, 19, 71, 135), again mirroring the processes seen in human IBD. The gene discussed is IL6; the disease is inflammatory bowel disease.