Ablation of AKAP150 in mice with long QT syndrome 8 (LQT8), a disease also known as Timothy syndrome characterized by sinus bradycardia, prolonged QT interval and lethal arrhythmias, restores normal gating in Cav1.2-LQT8 channels and protects the heart from arrhythmias (Cheng et al., 2011). The gene discussed is CACNA1C; the disease is long QT syndrome 8.