TP53 and cancer: This essential role of p53 in normal differentiation, beyond its roles in cell cycle control, is now well-documented in aspects of neurogenesis (Hardwick et al., 2014) and supports the notion that certain cancers may arise from a failure of differentiation rather than overt proliferation defects per se; a concept also suggested using a Xenopus developmental model for paediatric cancer Neuroblastoma (Wylie et al., 2015).