The study found that IRE1α signaling pathway was first activated after giving the mice a single carbon tetrachloride (CCl4) stimulus, (Lin et al., 2007; Hetz et al., 2011) and one of our previous study found that IRE1α signaling was first activated in CCl4-induced liver fibrosis (Wang et al., 2013). Here, ERN1 is linked to Hepatic fibrosis.