Moreover, cardiac-specific βARKct overexpression prevents cardiac remodeling and development of HF in MLP KO mice, a model of dilated cardiomyopathy with elevated GRK2 levels in the heart, suggesting that inhibition of GRK2 activity represents an approach to prevent the development of HF (Rockman et al., 1998). The gene discussed is GRK2; the disease is dilated cardiomyopathy.