Therefore, exciting the autonomic nervous system is regarded as a promising therapeutic strategy for treating RA (Ulloa et al., 2017).β2-AR signaling impairs IL-17 receptor induced maturation and anti-collagen II autoantibody production of B cells in mice with collagen induced arthritis (CIA) (Pongratz et al., 2014). This evidence concerns the gene ADRB2 and rheumatoid arthritis.