ASCL1 and central nervous system cancer: In line with these findings, R2 analysis of ASCL1 and NDRG1 expression in the Tumor Glioma French dataset indicated that NDRG1 expression was significantly increased in (a) high-grade as compared to low-grade gliomas and (b) IDH1 wild type vs. IDH1 mutant gliomas, while ASCL1 expression showed the opposite trend (Supplementary Fig. 3a, b).