Given that deregulation of the interplay between ASCL1 and NDRG1 might be considered as an initiating molecular event involved in the progression from PN to MES subtypes, a better understanding of the mechanisms underlying gene expression changes (e.g., microenvironment-induced gene repression and derepression, etc.)may lay the foundation for the identification of therapeutic strategies specifically targeted to restrain PMT and GBM evolution. This evidence concerns the gene NDRG1 and poikiloderma with neutropenia.