As such, we asked whether subgroup-specific gene classifiers could be pinpointed and endorsed  as subsidiary diagnostic/prognostic markers and potentially actionable vulnerabilities for GBM, as documented for subgroup-restricted molecular mediators, such as STAT3, CEBPB/D, TAZ, Olig2, MLK4, and DGKα [32] [33, 15, 14, 34]. Here, MAP3K21 is linked to glioblastoma.