In support of the idea that the uncoupling of the regulation of TYMS by FOXM1 is uniquely important for 5-FU insensitivity in HuCCA cells, our preliminary data show that, despite HuCCA being the most resistant to 5-FU treatment among all the CCA cells tested, it is one of the more, if not most, sensitive to epirubicin and paclitaxel treatment (Supplementary Fig. S9). The gene discussed is TYMS; the disease is cholangiocarcinoma.