TYMS and cholangiocarcinoma: Silencing of FOXM1 did not overtly affect 5-FU sensitivity of the resistant HuCCA cell line but caused a decrease in the clonogenicity of KKU-D131 (Fig. 4b), suggesting that FOXM1 plays a significant role in modulating TYMS expression and hence 5-FU sensitivity in the sensitive but not in the resistant CCA cells.