COXFA4L2 and nonpapillary renal cell carcinoma: Taken together these findings, in association with the particular metabolomic profile (partitioned metabolic flux through glycolysis), are suggestive of an altered mitochondrial function in ccRCC (impaired mitochondrial bioenergetics and oxidative phosphorylation, and NDUFA4L2 overexpression), and indicate the activation of compensatory mechanisms to keep mitochondrial ROS under control, in association with increased levels of cellular antioxidants (glutathione, tocopherol, and ascorbate).