Recent reports by others suggested that IL-8 [30], CCL20 [31], and the TLR4/IL10 signaling pathway [15] might be associated with EMT-induction in an in vitro culture system, and further investigations will be necessary to uncover the precise mechanism of EMT induction through the interplay between pancreatic cancer and TAMs. The gene discussed is TLR4; the disease is familial pancreatic carcinoma.