It is now clear that FLI1 promotes tumor growth by regulating a variety of target genes, including Bcl-2 in the regulation of apoptosis, gata-1 and RB1 in erythroid differentiation, MDM2 in the destabilization of the anti-apoptotic protein P53, VEGF-A in angiogenesis, and the Notch1 signaling pathway [1, 11, 25–28]. The gene discussed is NOTCH1; the disease is neoplasm.