SKA1 and lip and oral cavity carcinoma: Indeed, previous studies have shown that SKA1 upregulation enhances cell proliferation by promoting cell cycle progression in prostate cancer, gastric, bladder, and oral cancers [9–11, 31, 32], whereas depletion of SKA1 expression using RNA interference causes cell cycle arrest in cancer cells possibly by inhibiting the expression of cyclin D1 and CKD4 [31, 32].