Besides, SKA1 upregulation is significantly associated with the metastasis of NSCLC [23], and cell studies have revealed that knockdown of SKA1 expression by siRNA represses the invasion and metastasis of a range of cancer types, including renal cell carcinoma, salivary adenoid cystic carcinoma, prostate cancer, glioblastoma and NSCLC [23, 29, 31, 33]. This evidence concerns the gene SKA1 and Familial prostate cancer.