Enriched pathways for upregulated DEGs in L. mandarinus were associated with angiogenesis (HIF-1 signaling, bladder cancer, and AGE-RAGE signaling pathway in diabetic complications), transendothelial migration (leukocyte transendothelial migration and cell adhesion molecules), angiogenesis inhibition, cell cycle arrest for cell repair, and apoptosis (p53 signaling pathway). This evidence concerns the gene TP53 and urinary bladder carcinoma.