We then established transgenic flies, where CncC/Nrf2 OE was combined with InR or Pdpk1 KD and found that both genetic interventions largely rescued the CncC/Nrf2 OE‐mediated larval growth retardation (Figure 5a) and mitigated CncC/Nrf2 OE‐induced hyperglycemia in adult flies (Figure 5b). The gene discussed is PDPK1; the disease is Hyperglycemia.