Overexpression of DcR3 is thought to promote cancer progression.4, 9, 12, 17, 18, 44, 45 TPL has been shown to inhibit tumor growth in pancreatic cancer via the downregulation of DcR3 expression.39 In the current study, TPL suppressed tumor growth and repressed the expression of DcR3 in vitro, in vivo, and in PDTX models of OSCC (Figures 3 and 4), suggesting that the antitumor effects of TPL are exerted via repression of DcR3 expression in OSCC. This evidence concerns the gene TNFRSF6B and pancreatic neoplasm.