KLF12 and cancer: Several studies showed that the expression of KLF5 was downregulated or absent in patients with GC,29 and similar reduction was also occurred in other cancers, including prostate, breast, esophageal, and intestinal cancer.22, 24, 25 Nakamura et al11 showed that KLF12 level was remarkably upregulated for patients with GC and the knockdown of KLF12 induced growth arrest and significantly inhibited GC cell proliferation and invasion.