KLF5 and neoplasm: The explanation for this fact may be that the SNP of rs9564966 G > A affected the expressions and functions of the nearest upstream and downstream genes, including KLF5 and KLF12.3 The polymorphism of rs9564966 G > A may reduce KLF5 expression and improve KLF12 level through different mechanisms, exerting vital roles in tumor progression.