Li suggested that pre‐treatment with tetramethylpyrazine enhanced homing of MSCs to the ischaemic brain in a rodent model of stroke by upregulating CXCR4.50 However, Li also reported that increased expression of CXCR4 in MSCs by ultrasound‐targeted microbubble destruction was positively associated with the number of MSCs that migrated to infarcted areas of myocardium.51 The effect of autophagy on expression of CXCR4 in cells is unclear. Here, CXCR4 is linked to Stroke.