Singh et al showed that SIRT6 and hexokinase 2 activated autophagy and upregulated expression of CXCR4 in monocytes.52 However, stimulation of chemotactic G protein‐coupled receptors enhanced expression of CXCR4 in glioblastoma cells by suppressing formation of autophagosomes.53 In the present study, we first demonstrated that induction of autophagy by rapamycin enhanced the expression of CXCR4 on UC‐MSCs, as indicated by upregulation of the mRNA and protein expression of CXCR4 in UC‐MSCs, whereas 3‐MA significantly blocked these changes. Here, SIRT6 is linked to glioblastoma.