Additional γ‐H2AX (p‐serine 139) was performed as an indicator of DNA fragmentation and apoptosis.28 The results showed that all treatments resulted in increased γ‐H2AX IHC staining vs. control, however only RO6839921 alone led to a statistically significant increase in NB1691‐Luc tumours and temozolomide alone led to a statistically significant increase in SHSY5Y‐Luc tumours (Fig. S4A,B, Supporting Information). This evidence concerns the gene H2AX and neoplasm.