Several SNPs have been identified in the noncoding regions of BCL2 including rs1564483 (G>A) a functional variant in the BCL2 3′ UTR that is associated with decreased risk for non‐small‐cell lung cancer (NSCLC) (Xu et al., 2013) while yet another variant rs2279115 (C>A) appears to increase risk of esophageal SCC (Pan et al., 2015). The gene discussed is BCL2; the disease is non-small cell lung carcinoma.