Extracellularly, LOXL2 has been shown to signal through β‐integrin in cancer‐associated fibroblasts20 and intracellularly, LOXL2 and LOXL3 have been associated with epithelial to mesenchymal transition (EMT).21, 22, 23 Additionally, LOXL2 is a key player for heterochromatin formation via Snail‐dependent mechanisms.21, 22, 24 Moreover, one study showed that LOXL2 is a negative regulator of Notch1 transcription, thereby attenuating epidermal differentiation.25 The gene discussed is LOXL2; the disease is cancer.