In our current study, analysis of the liver revealed that the content of immature (DHLNL and HLNL) and mature (PYD and DPD) crosslinked collagen was increased upon the induction of liver fibrosis and that dual inhibition of the enzymatic functions of both LOXL2/LOXL3 reduced formation of these crosslinks. This evidence concerns the gene LOXL2 and Hepatic fibrosis.