CD40LG and Sepsis: The beneficial effect of IgM could be ascribed to its pentameric structure, including the neutralization of exo- and endotoxins, the enhancement of opsonization and phagocytosis and the increased bacterial lysis obtained via the activation of the alternative pathway of the complement system [12–21]; moreover, besides these anti-infective actions, IgM molecules have also some immunomodulatory effects such as the scavenging of excessive complement factors and the blunting of the production of some sepsis mediators [22].