CHRNA7 and schizophrenia: The α7 nAChR agonists and positive allosteric modulators (PAMs) have been reported to alleviate the negative and cognitive symptoms associated with schizophrenia in acute ketamine-induced rat models (Nikiforuk et al. 2016; Potasiewicz et al. 2017) and subchronic PCP mouse models (Pedersen et al. 2014).