The identified C1R mutation c.149_150TC>AT (p.Val50Asp) segregated with 15 individuals clinically affected by periodontal EDS in this family; in Fig. 1, only individuals relevant for the present study are depicted, with the same numbers as used in Kapferer-Seebacher et al. [1]. This evidence concerns the gene C1R and Ehlers-Danlos syndrome, periodontitis type.