GRIN2B and Blindness: In conclusion, prolonged visual deprivation that is associated with the onset of complete blindness in juvenile mice is associated with a large-scale upregulation of GluN2B expression through primary and secondary sensory cortices and the hippocampus, as well as a downregulation of GABA-A receptor expression that is localized to the somatosensory and posterior parietal cortices, and hippocampal dentate gyrus and CA1 regions.