Chronic kidney disease (CKD) is recognized as an independent risk factor forcardiovascular disease, which is the leading cause of death in this population.Mineral bone metabolism disorders and CKD (CKD-MBD) are a syndrome defined bychanges in calcium (Ca), phosphorus (P), vitamin D and parathyroid hormone (PTH),bone abnormalities and extra skeletal calcification. This evidence concerns the gene PTH and Marchiafava-Bignami disease.