HMOX1 and diabetic neuropathy: Conflicting findings have been obtained regarding the effects of HO-1 induction on δ-opioid agonists or cannabinoid-2 agonists during neuropathic pain.7,19,33 Although HO-1 induction in diabetic neuropathy enhances the antiallodynic effects of δ-opioid agonists or cannabinoid-2 agonists, HO-1 induction decreases the antiallodynic effects of δ-opioid agonists or cannabinoid-2 agonists in neuropathic pain induced by chronic constriction of the sciatic nerve.