However, quantitative analysis of copy number, mutation status, promoter methylation, and deletions may also be informative for other key genes implicated in the pathophysiology of different GBM subtypes, including epidermal growth factor receptor (EGFR), ATRX, cyclin-dependent kinase 4 (CDK4), CDKN2A/B, and Tert. This evidence concerns the gene EGFR and glioblastoma.