Similar to PD-1, Tim-3 is a marker of T cell exhaustion, and Lag-3 is a negative regulator of T cell and NK cell expansion.96 Both factors promote generation of Tregs.71 However, inhibitors of these factors have just been initiated in clinical trials.97 Tumor-specific dendritic cell vaccines and those targeting peptides overexpressed on GBM cells, such as cytomegalovirus, are in trials and chimeric TCR therapies are under development. The gene discussed is HAVCR2; the disease is glioblastoma.