INS and Glucose intolerance: Reductions in IL-6 secretion could also contribute to the development of subclinical diabetes (pre-diabetes) reported to occur during spaceflight since, as previously noted, IL-6 can increase pancreatic beta cell viability, insulin secretion, and CNS insulin sensitivity, and prevent the occurrence of obesity, glucose intolerance, and insulin resistance in mice fed obesogenic diets.85–88,94