Moreover, through the experiments in vivo and in vitro, we found that Ophiocordyceps sinensis could significantly inhibit the high expression of P2X7R and the activation of NLRP3 inflammasome in podocytes, which may be one of the important mechanisms for the therapeutic effects of Ophiocordyceps sinensis on DN. The gene discussed is NLRP3; the disease is liver dysplastic nodule.