SELE and acute lymphoblastic leukemia: Furthermore, there are some reports stating that there are increased levels of soluble intercellular adhesion molecule-1 (sICAM-1) [10], soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin [11], thrombomodulin, and von Willebrand factor [12] in ALL children at the time of diagnosis, which indicates that ED may be present before the treatment begins.