According to the above research, our team screened for a group of highly expressed refractory-related proteins in relapsed/refractory ABC-DLBCL patients including NF-κB p65, Stat3, Bcl2, Syk, BTK, Pax5, Bcl6, c-myc, and P57KIP2 by tissue chip. This evidence concerns the gene BTK and diffuse large B-cell lymphoma.