BCR and diffuse large B-cell lymphoma: The most frequently (≥10% of all samples) mutated genes in DLBCL belong to pathways controlling cell cycle, DNA damage response, chromatin remodeling, BCR and TLR signaling (125, 128–133) Additional genes were found to be mutated in a lower percentage of samples, but potentially relevant to DLBCL biology, including genes belonging to the NOTCH family.