A growing number of evidence indicated that MALAT1 was closely related to various pathological processes, including diabetes complications and hepatic carcinoma [15], and could influence the progression of hepatic fibrosis by repressing the expression and function of silent information regulator 1 [SIRT1, a Nicotinamide adenine dinucleotide (NAD)-dependent class III protein deacetylase] [16]. The gene discussed is SIRT1; the disease is Hepatic fibrosis.