CRH and Anxiety: These results are considered to be in the same direction as other results, including brain imaging findings related to anxiety caused by abdominal pain stimulation [13]; amygdala activation in IBS patients [14]; strong activation of the amygdala when IBS patients are administered the stress-related peptide CRH [15]; remarkable abdominal pain-related activation in IBS patients against anxiogenic stimuli [16]; and the correlation between stressful life events and the exacerbation of GI symptoms in IBS patients but not in FBD patients or healthy controls [17].