RNASE3 and eosinophil disorder: Moreover, the presence of clusters of free intact, membrane-bound eosinophilic granules (FEGs) and cationic granule proteins [major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil-derived neurotoxin, and eosinophil peroxidase (EPX)] have been identified in inflammatory foci in eosinophilic diseases (5, 6).