Leptin receptor Q223R mutation leads to defective STAT3 signaling pathway and associated with an increased risk of colitis.Mutation of tyrosine 1,138 in the intracellular domain of LepRb decreased mucosal chemokine and cell recruitment.Increases inflammation, colonic chemokine expression, and cellular recruitment.Improve the bacterial clearance. The gene discussed is LEPR; the disease is colitis.