Interestingly, very recently we demonstrated that leptin also induces a protective CD8+ T-cell dependent immune response in malnutrition coupled with L. donovani infection through up-regulation of Granzyme A (GrzA) and down-regulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and Programmed death-1 (PD-1) markers (132). The gene discussed is CD8A; the disease is nutritional deficiency disease.