Although CD4+CD8+ DP T cells represented less than 2% of T cells in a majority of tumor samples, frequencies of CD4+CD8+ DP T cells above 5% of T cells were observed in 6/21 of RCC samples, 1/16 lung cancer and 1/16 CRC samples (Figure 1B). The gene discussed is CD8A; the disease is renal cell carcinoma.