The expanded DP T cell subset observed in the lung cancer patient (6.5% of T cells) showed a different profile with CD4 expression similar to CD4 T cells (ratio of CD4 MFI in DP over CD4 MFI in CD4: 0.97) and significantly lower CD8 expression than CD8 T cells (ratio of CD8 MFI in DP over CD8 MFI in CD8 cells: 0.33) (Figures 1C,D). The gene discussed is CD8A; the disease is lung carcinoma.