IL-6 is known for its capability to promote differentiation of Th2 cells (35), to inhibit Th1 and Treg differentiation and expansion in response to allergen, to activate immunoglobulin class-switching in plasma cells and to enhance the differentiation of Th17 cells (36), which are engaged in amplification of severe asthma, and to control airway remodeling (37). The gene discussed is IL6; the disease is asthma.