Our results showed that ablation of IL-6 signaling as seen in IL-6 KO mice abrogated the increase in granulocyte and Th2 cell numbers in the airways (Figure 1B), secretion of IgE in BALF and serum (Figure 1C), expression of asthma-associated genes, such as Tslp, Tgfb1, Muc5ac, Gob5, Il4 (Figures 1D,E), and mucus production in the lungs (Supplementary Figure 3) in the low-dose HDM-induced asthma. This evidence concerns the gene CLCA1 and asthma.