ITGAX and asthma: To specifically address the role of IL-6 produced by dendritic cells in allergic airway inflammation, we used mice with tissue-restricted inactivation of IL-6 in CD11c+ cells (CD11c-IL-6 KO) (23) and subjected them, together with IL-6 KO mice and littermate WT control mice, to HDM-induced asthma model (Figure 5).