Since it was identified that TNF-α secretion by adipocytes played a role in the body's update of glucose and response to insulin which contributes to the development of diabetes (Hotamisligil et al., 1993), extensive research has been done looking at the role of inflammation in diabetes (Wellen and Hotamisligil, 2005; Calle and Fernandez, 2012). The gene discussed is INS; the disease is diabetes mellitus.