It has been demonstrated that renalase supplementation by adenoviral transduction attenuated hypertension, LVH, fibrosis and the cardiac expression of NADPH-oxidase components gp91phox, p47phox, and p67phox in partially nephrectomized rats (Yin et al., 2016) (Table 1). The gene discussed is FMO5; the disease is hypertensive disorder.