Gaetano Perusini and Alois Alzheimer firstly described AD at the beginning of the 20th century (Macchi et al., 1997) with their studies on AD anatomopathological hallmarks represented by amyloid-β (Aβ) plaques and neurofibrillary tangles (aggregates of hyperphosphorylated tau protein), cortical atrophy and gliosis (Papa et al., 2014; Reiman, 2014). Here, MAPT is linked to Alzheimer disease.