From this perspective, the C-type lectin-like receptor 2 (CLEC-2)A plays a key role in mediating tumor interactions; it binds to podoplanin, physiologically expressed on kidney podocytes and lymphatic endothelial cells, protecting the tumor from the immune system aggression and inducing platelet aggregation and tumor metastasis progression (Suzuki-Inoue et al., 2007). The gene discussed is PDPN; the disease is neoplasm.