The direct involvement of ADNP in cognitive function was reported in our 2007 Adnp haploinsufficient mouse model (Vulih-Shultzman et al., 2007) coupled with a paper showing that deletion in the chromosomal area including ADNP [20q12–13.2 (Zamostiano et al., 2001)] specifically, 20q13.13–q13.2 (Borozdin et al., 2007) resulted in developmental delays and intellectual disabilities in humans. The gene discussed is ADNP; the disease is Global developmental delay.