SNCA and Parkinson disease: It has been proposed that DAC can induce aggregation of α-synuclein and eventual Lewy body deposition through formation of a DAC-synuclein adduct (Berman and Hastings, 1999; Conway et al., 2001; Bianco et al., 2002; Norris et al., 2005), and α-synuclein mRNA has a predicted iron-response element in the 5′-untranslated region similar to the Fe-storage protein ferritin (Friedlich et al., 2007), suggesting this hallmark protein of Parkinson's disease also plays a role in Fe-mediated toxicity within vulnerable neurons.