Variation in pH reflecting transition from a physiologically normal microchemical environment to Parkin-associated mitochondrial dysfunction (Pickrell and Youle, 2015) and post-mortem acidosis (Donaldson and Lamont, 2013) had a marked effect on DAC and H2O2 production concomitant to pH-dependent oxidation of Fe[II]. Here, PRKN is linked to acidosis disorder.